The Optispan Podcast with Matt Kaeberlein
by Matt Kaeberlein · Optispan
Free video series from a biogerontologist who spent two decades running an academic aging lab, covering rapamycin, metformin, biological-age tests and supplement claims, and regularly explaining why specific popular longevity assertions fail on the evidence.
More resources on Longevity & the Science of Aging
FoundMyFitness
Long-form interviews and solo episodes from biomedical scientist Rhonda Patrick, covering nutrition, micronutrients, sauna and cold exposure, exercise, and aging. Episodes work through the underlying studies, so you can judge the evidence behind common health claims.
Outlive: The Science and Art of Longevity
Physician's framework for extending healthspan, arguing for early risk assessment and heavy emphasis on cardiorespiratory fitness, strength, lipids, glucose and sleep. Evidence quality varies by chapter; the exercise and metabolic sections rest on the strongest data. Covers the exercise/nutrition/sleep half better than any other single accessible source, and its strongest material - VO2max and muscular strength as mortality predictors, ApoB rather than LDL-C as the lipid target, the case for acting decades before disease onset - sits on genuinely solid epidemiology.
Ageless: The New Science of Getting Older Without Getting Old
Popular-science tour of aging biology organised around the hallmarks framework: senescent cells, telomeres, stem-cell exhaustion, epigenetic change and the trials now testing them. Written by a computational biologist, and openly optimistic about the field's prospects.
A Science-Based Review of the World's Best-Selling Book on Aging
Peer-reviewed rebuttal of David Sinclair's Lifespan, walking through the sirtuin, resveratrol and partial-reprogramming claims and the replication failures behind them. A short, concrete case study in checking a popular longevity narrative against the primary literature.
senescence.info - The Science of Ageing
Academic portal maintained by a molecular biogerontology chair at Birmingham, covering aging theories, evolutionary biology, cellular senescence, telomeres and caloric restriction, plus sceptical essays on anti-aging medicine and the GenAge, DrugAge and AnAge databases.
NIA Interventions Testing Program (ITP)
Program page for the NIH-funded trials that test candidate lifespan-extending drugs in genetically heterogeneous mice at three independent sites. Lists compounds tested, published survival results for rapamycin, acarbose, canagliflozin and others, and links the underlying data. The ITP is the only place where 'drug X extends lifespan' has been tested to a standard that survives replication, and most celebrated compounds failed there. It answers the metformin and rapamycin questions in the topic note with actual survival curves rather than mechanism stories.