---
title: CRISPR Technology
description: CRISPR technology focuses on the mechanisms and applications of RNA-guided gene editing. Learners will understand how the Cas9 system targets and modifies DNA sequences, its therapeutic potential, and its use in agricultural biotechnology.
category: sciences
subcategory: biotechnology
difficulty: beginner, intermediate, advanced
url: /subject/crispr-technology
---

# CRISPR Technology

CRISPR technology focuses on the mechanisms and applications of RNA-guided gene editing. Learners will understand how the Cas9 system targets and modifies DNA sequences, its therapeutic potential, and its use in agricultural biotechnology.

## Available Resources

1 Videos • 3 Books • 3 Websites

## Websites

### 1. CRISPR Journal

Peer-reviewed journal from Mary Ann Liebert publishing primary research, reviews, and commentary on genome editing, spanning delivery methods, base and prime editing, agriculture, therapeutics, and the policy debates around clinical use.

**Difficulty:** Beginner | **Price:** Free

**Link:** https://www.liebertpub.com/loi/crispr

**Tags:** crispr, genome-editing, peer-reviewed-research, journal, biotechnology

### 2. Addgene CRISPR Guide

Reference pages from the nonprofit plasmid repository explaining Cas9 biology, guide design, delivery, and screening, with links to validated plasmids and bench protocols. Gives newcomers enough grounding to plan a first editing experiment.

**Difficulty:** Beginner | **Price:** Free

**Link:** https://www.addgene.org/guides/crispr/

**Tags:** crispr, addgene, plasmids, lab-protocols, genome-editing

### 3. addgene.org

Addgene is a nonprofit plasmid repository and resource for genetic engineering. It provides access to thousands of plasmids and CRISPR tools, plus detailed protocols, educational materials, and community resources for researchers.

**Difficulty:** Intermediate | **Language:** English | **Price:** Free

**Link:** https://addgene.org

**Tags:** websites, engineering-manufacturing, biotechnology

## Videos

### 1. Genome Editing with CRISPR-Cas9

Short animation from MIT's McGovern Institute, made with Feng Zhang's lab, showing how Cas9 is guided to a DNA target, cuts both strands, and how the repair pathways enable gene knockout or insertion.

**Difficulty:** Beginner | **Price:** Free

**Link:** https://www.youtube.com/watch?v=2pp17E4E-O8

**Tags:** crispr, cas9, genome-editing, animation, molecular-biology

## Books

### 1. A Crack in Creation

**Author:** Jennifer A. Doudna, Samuel H. Sternberg

First-hand account from the Berkeley lab that developed CRISPR-Cas9 as an editing tool, tracing the bacterial immunity research behind it and then confronting germline editing, patents, and the ethics of a technology moving faster than its oversight.

**Difficulty:** Intermediate | **Language:** English | **Price:** Paid

**Link:** https://www.amazon.com/dp/1328915360?tag=edmonddante07-20

**Tags:** books, engineering-manufacturing, biotechnology

### 2. The Code Breaker

**Author:** Walter Isaacson

Biography of Jennifer Doudna that doubles as a narrative history of CRISPR, covering the race between competing labs, the patent fight with the Broad Institute, and the ethical arguments over editing human embryos.

**Difficulty:** Intermediate | **Language:** English | **Price:** Paid

**Link:** https://www.amazon.com/dp/1982115858?tag=edmonddante07-20

**Tags:** books, engineering-manufacturing, biotechnology

### 3. CRISPR People

**Author:** Henry T. Greely

Bioethicist and law professor Henry T. Greely reconstructs He Jiankui's 2018 gene-edited babies case, then examines the science, regulation, and ethical arguments around heritable human genome editing and when, if ever, it should be permitted.

**Difficulty:** Intermediate | **Language:** English | **Price:** Paid

**Link:** https://www.amazon.com/dp/0262543885?tag=edmonddante07-20

**Tags:** books, engineering-manufacturing, biotechnology

---

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