--- title: Biophysics description: Biophysics applies physics to living systems. You will learn molecular motors and membranes, statistical physics of biomolecules, imaging techniques and the quantitative methods of modern biology. category: sciences subcategory: physics difficulty: beginner, intermediate, advanced url: /subject/biophysics --- # Biophysics Biophysics applies physics to living systems. You will learn molecular motors and membranes, statistical physics of biomolecules, imaging techniques and the quantitative methods of modern biology. ## Available Resources 4 Books • 1 Courses ## Courses ### 1. iBiology Microscopy Series **Author:** Ron Vale, Nico Stuurman, Kurt Thorn This is the standard free microscopy course for life scientists. Free video course directed by Ron Vale, Nico Stuurman and Kurt Thorn. It covers optics and image formation, contrast methods, fluorescence and GFP, cameras, deconvolution, super-resolution and optical traps, through lectures, labs filmed at the microscope and an assessment for each lecture. **Difficulty:** Beginner | **Language:** English | **Price:** Free **Link:** https://www.ibiology.org/online-biology-courses/microscopy-series/ **Tags:** light-microscopy, fluorescence-microscopy, super-resolution, optics, image-formation ## Books ### 1. Biophysics: Searching for Principles **Author:** William Bialek This is the capstone after Nelson and PBoC, and the principles-first theoretical approach it represents cannot be found elsewhere. It is only for readers with graduate-level physics. Graduate biophysics text for physics students, organized around general principles. It treats noise limits in photon counting and chemical sensing, robustness without fine-tuned parameters, and information flow in gene regulation, embryonic development, neural coding and perception. It assumes strong statistical mechanics. **Difficulty:** Advanced | **Language:** English | **Price:** Paid **Link:** https://www.amazon.com/dp/0691138915?tag=edmonddante07-20 **Tags:** theoretical-biophysics, statistical-mechanics, information-theory, gene-regulation, neural-coding ### 2. Cell Biology by the Numbers **Author:** Ron Milo, Rob Phillips Free online book by Ron Milo and Rob Phillips, written as short vignettes that each answer a quantitative question about cells. It covers sizes, copy numbers, concentrations, energies, forces, rates and error frequencies, using measured values and back-of-the-envelope estimates. It is the easiest way in for readers who have not yet built physical intuition for cells. The full text is free online. **Difficulty:** Beginner | **Language:** English | **Price:** Free **Link:** https://book.bionumbers.org/ **Tags:** quantitative-biology, cell-biology, order-of-magnitude-estimation, bionumbers, biophysics ### 3. Physical Biology of the Cell (2nd Edition) **Author:** Rob Phillips, Jane Kondev, Julie Theriot, Hernan G. Garcia This is the reference text of the 'physical biology' school. It goes deeper than Nelson on gene regulation, networks and cell-scale modeling, and it serves biology readers well, which is why it is also cross-listed to cell and molecular biology. Comprehensive textbook that builds simple physical models of cells. It covers the statistical mechanics of binding, two-state systems, random walks, DNA and polymer mechanics, membranes, molecular motors, gene regulation and biological networks, with order-of-magnitude estimates and computational problems. **Difficulty:** Intermediate | **Language:** English | **Price:** Paid **Link:** https://www.amazon.com/dp/0815344503?tag=edmonddante07-20 **Tags:** physical-biology, statistical-mechanics, molecular-motors, gene-regulation, biological-networks ### 4. Biological Physics (Student Edition): Energy, Information, Life **Author:** Philip Nelson It is the most widely recommended first book on the subject and covers every item in the topic note except imaging. Introductory biological physics textbook that needs only first-year physics and calculus. It covers diffusion, entropy and free energy, self-assembly, molecular motors, membranes, nerve impulses and single-molecule experiments, with problems throughout. The 2020 Student Edition updates the chapter on motors. **Difficulty:** Intermediate | **Language:** English | **Price:** Paid **Link:** https://www.amazon.com/dp/057868702X?tag=edmonddante07-20 **Tags:** biological-physics, diffusion, free-energy, molecular-motors, membranes ## Youtubes ### 1. Physical Biology of the Cell Lectures (Caltech BE/APh 161) **Author:** Rob Phillips This is the best free video companion to the core textbooks, taught directly by the field's leading pedagogue. The videos are short, topic-based vignettes rather than full-length lectures, so they work best alongside the book. Official video channel for Rob Phillips' Caltech course BE/APh 161, with about 170 short lectures. Topics include binding and allostery, the chemical potential, ion channels, biological batteries, DNA elasticity and data collapse. The videos accompany the Physical Biology of the Cell textbook. **Difficulty:** Intermediate | **Language:** English | **Price:** Free **Link:** https://www.youtube.com/channel/UCnYEe45w6F4G3AEYCyNHMWg/videos **Tags:** physical-biology, statistical-mechanics, ion-channels, dna-mechanics, biophysics --- *This content is part of Dantes.io - Your Treasure Map to Knowledge* *Curated by humans at Dantes.io. Personal study use welcome; republishing this curation requires permission (team@dantes.io).* View this page online: https://dantes.io/subject/biophysics